Hydrochloric Acid → HCID 20361483, compound

HRID 1679610Notes

Reaction equation

HRID 1679610 reaction equation
CN.[CH3:3][NH:4][CH2:5][CH:6]1[CH2:11][CH:10]2[CH2:12][CH:8]([C:9]2([CH3:14])[CH3:13])[CH:7]1[CH3:15].[ClH:16]>>[ClH:16].[CH3:3][NH:4][CH2:5][CH:6]1[CH2:11][CH:10]2[CH2:12][CH:8]([C:9]2([CH3:14])[CH3:13])[CH:7]1[CH3:15]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 6329MethylamineHCID 20361480HCID 20361480, compound

Product 1

HCID 20361483HCID 20361483, compound

Procedure

The procedure of Example 7 is followed, using methylamine instead of ammonia. The (+)-3-methylaminomethylpinane boils at from 118° to 120° C/18 mm Hg. (+)-3-Methylaminomethylpinane hydrochloride of optical rotation [α]D23 = + 30.8° is prepared by treatment with hydrogen chloride, analogously to Example 7. The (+)-3-methylaminomethylpinane hydrochloride obtained after two recrystallizations from a mixture of ethyl acetate and methanol has an optical rotation of [α]D23 = + 44.0° and melts at 240° C.

Workup

  1. customboils at from 118° to 120° C/18 mm Hg

Sources & evidence

ORD record
ord-aa46344f87714e1f8e6c4ca3149ff1d1
Source dataset
uspto-grants-1978_03
Patent number
US04081477

Reaction notes

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