Potassium Carbonate → HCID 54246480, compound

HRID 1679716Notes

Reaction equation

HRID 1679716 reaction equation
[CH:1]1([C:6]2([CH3:19])[CH2:14][C:13]3[C:8](=[C:9]([Cl:17])[C:10]([Cl:16])=[C:11]([OH:15])[CH:12]=3)[C:7]2=[O:18])[CH2:5][CH2:4][CH2:3][CH2:2]1.[C:20]([O:24][C:25](=[O:28])[CH2:26]Br)([CH3:23])([CH3:22])[CH3:21].C(=O)([O-])[O-].[K+].[K+].O=C1C2C(=CC(OCC(OC(C)(C)C)=O)=C(Cl)C=2Cl)CC1C1CCCC1>O.CN(C)C=O>[O:18]=[C:7]1[C:8]2[C:13](=[CH:12][C:11]([O:15][CH2:26][C:25]([O:24][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:28])=[C:10]([Cl:16])[C:9]=2[Cl:17])[CH2:14][C:6]1([CH:1]1[CH2:2][CH2:3][CH2:4][CH2:5]1)[CH3:19]

Participants

7

Reactant 4

HCID 11430Potassium CarbonateHCID 79177tert-Butyl bromoacetateHCID 123955886,7-Dichloro-2-cyclopentyl-5-hydroxy-2-methylindan-1-oneHCID 86734061HCID 86734061, compound

Product 1

HCID 54246480HCID 54246480, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

A mixture of 2-cyclopentyl-2-methyl-5-hydroxy-6,7-dichloro-1-indanone (2.98 g., 0.01 mole), tert.-butylbromoacetate (2.15 g., 0.011 mole), potassium carbonate (2.76 g., 0.02 mole) and dimethylformamide (15 ml.) is stirred at 25° for 1 hour then poured into water (50 ml.) the tert.-butyl (1-oxo-2-cyclopentyl-6,7-dichloro-5-indanyloxy)acetate which separates is filtered, rinsed with water and dried.

Workup

  1. filtrationseparates is filtered
  2. washrinsed with water
  3. customdried

Sources & evidence

ORD record
ord-0e55eaaa9b504b32bb939441d1402520
Source dataset
uspto-grants-1978_03
Patent number
US04081554

Reaction notes

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