Trifluoroacetic acid → HCID 88813774, compound

HRID 1679783Notes

Reaction equation

HRID 1679783 reaction equation
[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:4]([NH:6][CH2:7][C:8]([O:10][CH3:11])=[O:9])=[O:5])[CH3:3].[F:19][C:20]([F:25])([F:24])[C:21]([OH:23])=[O:22]>>[F:19][C:20]([F:25])([F:24])[C:21]([OH:23])=[O:22].[CH3:11][O:10][C:8](=[O:9])[CH2:7][NH:6][C:4](=[O:5])[C@H:2]([CH3:3])[NH2:1]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 14158799HCID 14158799, compound

Product 1

HCID 88813774HCID 88813774, compound

Conditions

Temperature
0 °C

Procedure

Boc-Ala-Gly-OMe [10 g, 45 mmoles, described by H. U. Immer et al., Helv. Chim. Acta, 57, 730 (1974)] is dissolved in cold (ice bath) trifluoroacetic acid (100 ml). The solution is stirred for 1 hr at 0° C and the solvent evaporated. The residue is dissolved in methanol, added to diethyl ether and the precipitate collected to yield the title compound.

Workup

  1. customthe solvent evaporated
  2. dissolutionThe residue is dissolved in methanol
  3. additionadded to diethyl ether
  4. customthe precipitate collected

Sources & evidence

ORD record
ord-70b1e0cc27e8411d82ffa2ede26c0f25
Source dataset
uspto-grants-1978_03
Patent number
US04081530

Reaction notes

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