Hydrochloric Acid → HCID 88767897, compound

HRID 1679883Notes

Reaction equation

HRID 1679883 reaction equation
[ClH:1].[O:2]([CH2:4][C:5]1[NH:6][CH:7]=[CH:8][N:9]=1)[NH2:3].[NH2:10][C:11]1[S:12][CH:13]=[C:14]([C:16](=O)[C:17]([OH:19])=[O:18])[N:15]=1.C(=O)([O-])[O-].[K+].[K+].Cl>O>[ClH:1].[NH2:10][C:11]1[S:12][CH:13]=[C:14]([C:16](=[N:3][O:2][CH2:4][C:5]2[NH:6][CH:7]=[CH:8][N:9]=2)[C:17]([OH:19])=[O:18])[N:15]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 11430Potassium CarbonateHCID 127833204-Thiazoleacetic acid, 2-amino-alpha-oxo-HCID 23458248HCID 23458248, compound

Product 1

HCID 88767897HCID 88767897, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2 g of 2-[(aminoxy)methyl]-1H-imidazolehydrochloride (1:2) from example 1(b) and 2.24 g 2-amino-thiazol-4-glyoxylic acid are suspended with stirring in 50 ml H2O. The pH is adjusted with potassium carbonate to 6 and stirring is continued for 12 hours. The pH is then adjusted to 6.4 with hydrochloric acid. After 2 hours 0.8 of crystalline 2-amino-α-[(1H-imidazol-2-yl-methoxy)imino]-4-thiazole acetic acid hydrochloride (1:2) is filtered off with a melting point of 158°-160° C. (dec.).

Workup

  1. filtrationAfter 2 hours 0.8 of crystalline 2-amino-α-[(1H-imidazol-2-yl-methoxy)imino]-4-thiazole acetic acid hydrochloride (1:2) is filtered off with a melting point of 158°-160° C. (dec.)

Sources & evidence

ORD record
ord-42e87c24ed2c44b289d0b3f6b0eee361
Source dataset
uspto-grants-1981_06
Patent number
US04271157

Reaction notes

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