Phosphorus trichloride → HCID 6320223, compound

HRID 1679888Notes

Reaction equation

HRID 1679888 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[Br:12])[N+:8]([O-])=[C:7]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[C:6](=[O:19])[NH:5]2.P(Cl)(Cl)Cl>C1COCC1>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[Br:12])[N:8]=[C:7]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[C:6](=[O:19])[NH:5]2

Participants

4

Reactant 2

HCID 24387Phosphorus trichlorideHCID 13055390HCID 13055390, compound

Product 1

HCID 6320223HCID 6320223, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

One gram of ethyl 6-chloro-7-bromo-3,4-dihydro-3-oxo-2-quinoxaline carboxylate N-oxide was dissolved in 50 ml. of THF. Six ml. of phosphorus trichloride were added and the resulting mixture heated gently at refluxing temperature overnight. The reaction mixture was poured into 500 ml. of an ice-water mixture. A solid, comprising ethyl 6-chloro-7-bromo-3,4-dihydro-3-oxo-2-quinoxaline carboxylate formed in the above reaction, was separated by filtration; melting point=203°-205° C.; yield=0.6 g.

Workup

  1. temperaturethe resulting mixture heated gently
  2. temperatureat refluxing temperature overnight
  3. additionThe reaction mixture was poured into 500 ml

Sources & evidence

ORD record
ord-41e472627cd24742959a11f639d604a1
Source dataset
uspto-grants-1981_06
Patent number
US04271162

Reaction notes

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