Hydrochloric Acid → HCID 70574841, compound

HRID 1680014Notes

Reaction equation

HRID 1680014 reaction equation
[ClH:1].[NH2:2][CH:3]([CH:11]1[NH:15][CH:14]([C:16]([O:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[O:17])[C:13]2([CH2:30][CH2:29][N:28]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)[CH2:27][CH2:26]2)[S:12]1)[C:4]([O:6]C(C)(C)C)=[O:5]>[N+](C)([O-])=O>[ClH:1].[ClH:1].[NH2:2][CH:3]([CH:11]1[NH:15][CH:14]([C:16]([O:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[O:17])[C:13]2([CH2:26][CH2:27][N:28]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)[CH2:29][CH2:30]2)[S:12]1)[C:4]([OH:6])=[O:5]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 23458748HCID 23458748, compound

Product 1

HCID 70574841HCID 70574841, compoundYield 95.5%

Reagents, catalysts & solvents 1

HCID 6375NitromethaneSolvent

Procedure

A stream of gaseous hydrogen chloride is passed through a suspension of 11 g (0.0206 mole) of tert-butyl alpha-amino-4-benzyloxycarbonyl-8-phenyl-1-thia-3,8-diazaspiro[4.5]decane-2-acetate (obtained in 4.3) in 200 ml of nitromethane. After 1 hour, a clear solution is obtained which is filtered through "Hyflocel" and the filtrate is evaporated to dryness. The residue is taken up in diethyl ether, filtered and washed with diethyl ether. There are obtained 9.4 g of alpha-amino-4-benzyloxycarbonyl-8-phenyl-1-thia-3,8-diazaspiro[4.5]decane-2-acetic acid dihydrochloride. Yield: 95.5%; M.P. 164°-167° C. (decomposition).

Workup

  1. customa clear solution is obtained which
  2. filtrationis filtered through "Hyflocel"
  3. customthe filtrate is evaporated to dryness
  4. filtrationfiltered
  5. washwashed with diethyl ether

Sources & evidence

ORD record
ord-32495cf419ef4049971c87f55029ec50
Source dataset
uspto-grants-1981_06
Patent number
US04271172

Reaction notes

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