HRID1680018

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6101

4-Methylbenzenesulfonic acid

C7H8O3S

结构：O=C(OCc1ccccc1)C1N2C(=O)C(NC(c3ccccc3)(c3ccccc3)c3ccccc3)[C@H]2SC12CCN(c1ccccc1)CC2

HCID70577387

未命名化合物

PRODUCTS

生成物

结构：Cc1ccc(S(=O)(=O)O)cc1.Cc1ccc(S(=O)(=O)O)cc1.NC1C(=O)N2C(C(=O)OCc3ccccc3)C3(CCN(c4ccccc4)CC3)S[C@H]12

HCID86737760

未命名化合物

收率 92%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID180

Acetone

C3H6O

PROCEDURE

实验过程

A mixture of 1.33 g (0.002 mole) of benzyl 1'-phenyl-6-tritylamino-spiro [penam-2,4'-piperidine]-3-carboxylate (obtained in 7.3) and 0.76 g of p-toluenesulfonic acid in 10 ml of acetone is stirred at ambient temperature for 6 hours. After filtering and drying, there is obtained 1.40 g of benzyl 6-amino-1'-phenyl-spiro[penam-2,4'-piperidine]-3-carboxylate di-p-toluenesulfonate. Yield: 92%; M.P. 168°-169° C. (decomposition).

WORKUP

后处理

filtrationAfter filtering
customdrying

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-82e5c9f40d344e999ca516be25426ed9
来源数据集: uspto-grants-1981_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04271172
来源说明: uspto-grants-1981_06

反应 SMILES

[C:1]1([N:7]2[CH2:12][CH2:11][C:10]3([CH:16]([C:17]([O:19][CH2:20][C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=4)=[O:18])[N:15]4[C:27](=[O:49])[CH:28]([NH:29]C(C5C=CC=CC=5)(C5C=CC=CC=5)C5C=CC=CC=5)[C@H:14]4[S:13]3)[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:50]1([CH3:60])[CH:55]=[CH:54][C:53]([S:56]([OH:59])(=[O:58])=[O:57])=[CH:52][CH:51]=1>CC(C)=O>[C:50]1([CH3:60])[CH:51]=[CH:52][C:53]([S:56]([OH:59])(=[O:57])=[O:58])=[CH:54][CH:55]=1.[C:50]1([CH3:60])[CH:51]=[CH:52][C:53]([S:56]([OH:59])(=[O:57])=[O:58])=[CH:54][CH:55]=1.[NH2:29][CH:28]1[C:27](=[O:49])[N:15]2[CH:16]([C:17]([O:19][CH2:20][C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=3)=[O:18])[C:10]3([S:13][C@H:14]12)[CH2:11][CH2:12][N:7]([C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)[CH2:8][CH2:9]3