HRID1680053

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)Oc1ccc([N+](=O)[O-])cc1

HCID112124

4-Nitrophenyl N-((benzyloxy)carbonyl)-L-valinate

C19H20N2O6

结构：CC(C)C[C@H](NC(=O)[C@@H](N)[C@@H](C)O)C(=O)OC(C)(C)C

HCID131712120

未命名化合物

HCID131712254

未命名化合物

PRODUCTS

生成物

结构：CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)[C@@H](C)O)C(=O)OC(C)(C)C

HCID131712119

未命名化合物

收率 72%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

Coupling of 7.85 g Z-Val-ONp with 5.53 g H-Thr-Leu-OtBu in 160 ml DMF in the way described in C (2) provides Z-Val-Thr-Leu-OtBu in 72% yield.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-7fea017de74248d892c145bf1625bb1e
来源数据集: uspto-grants-1981_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04271152
来源说明: uspto-grants-1981_06

反应 SMILES

[CH3:1][CH:2]([C@H:4]([NH:17][C:18]([O:20][CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[O:19])[C:5]([O:7]C1C=CC([N+]([O-])=O)=CC=1)=O)[CH3:3].[NH2:28][C@H:29]([C:33]([NH:35][C@H:36]([C:41]([O:43][C:44]([CH3:47])([CH3:46])[CH3:45])=[O:42])[CH2:37][CH:38]([CH3:40])[CH3:39])=[O:34])[C@@H:30]([CH3:32])[OH:31].N[C@H](C(N[C@@H](C(OC(C)(C)C)=O)CC(C)C)=O)[C@@H](C)O>CN(C=O)C>[NH:17]([C:18]([O:20][CH2:21][C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1)=[O:19])[C@H:4]([C:5]([NH:28][C@H:29]([C:33]([NH:35][C@H:36]([C:41]([O:43][C:44]([CH3:47])([CH3:46])[CH3:45])=[O:42])[CH2:37][CH:38]([CH3:39])[CH3:40])=[O:34])[C@@H:30]([CH3:32])[OH:31])=[O:7])[CH:2]([CH3:1])[CH3:3]