Piperidine → HCID 23459047, compound

HRID 1680072Notes

Reaction equation

HRID 1680072 reaction equation
[C:1]1([C:7]([CH:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[OH:10])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.ClCCO[CH2:21][CH2:22]Cl.[NH:24]1[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1>CCOCC>[N:24]1([CH2:21][CH2:22][O:8][CH:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[O:10])[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1

Participants

4

Reactant 2

HCID 8082PiperidineHCID 23459030HCID 23459030, compound

Product 1

HCID 23459047HCID 23459047, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

With stirring, 27 g (0.1 mole) of benzoin-2-chloroethyl ether and 68 g (0.8 mole) of piperidine are kept for 6 hours at 110° C. After cooling, the product is taken up in ether and the ether layer is washed with water, dried over Na2SO4 and concentrated. The residual oil is taken up in hexane and the crystals obtained are recrystallised from hexane. Melting point: 53° C.

Workup

  1. temperatureAfter cooling
  2. washthe ether layer is washed with water
  3. dry with materialdried over Na2SO4
  4. concentrationconcentrated
  5. customthe crystals obtained
  6. customare recrystallised from hexane

Sources & evidence

ORD record
ord-2eeb51e5a6c847fb8c2afff1ab79308b
Source dataset
uspto-grants-1981_06
Patent number
US04271294

Reaction notes

Loading…