Piperidine → HCID 23459038, compound

HRID 1680073Notes

Reaction equation

HRID 1680073 reaction equation
Cl[CH2:2][CH2:3][O:4][C:5]([O:20][CH2:21][CH2:22]Cl)([C:12]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[O:13])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[NH:24]1[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1>CCOCC>[N:24]1([CH2:2][CH2:3][O:4][C:5]([O:20][CH2:21][CH2:22][N:24]2[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]2)([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=2)[C:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[O:13])[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1

Participants

4

Reactant 2

HCID 8082PiperidineHCID 14762563HCID 14762563, compound

Product 1

HCID 23459038HCID 23459038, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

With stirring, 35 g (0.1 mole) of benzil-di-(2-chloroethyl)ketal and 77 g (0.9 mole) of piperidine are kept for 7 hours at 105° C. After cooling, the reaction mixture is diluted with ether and the piperidine hydrochloride is collected by filtration. The ether is distilled off and the residual oil is dried in a high vacuum.

Workup

  1. temperatureAfter cooling
  2. filtrationthe piperidine hydrochloride is collected by filtration
  3. distillationThe ether is distilled off
  4. customthe residual oil is dried in a high vacuum

Sources & evidence

ORD record
ord-18c53d81939a4726979fb91588587085
Source dataset
uspto-grants-1981_06
Patent number
US04271294

Reaction notes

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