Hydrochloric Acid → HCID 12898562, compound

HRID 1680261Notes

Reaction equation

HRID 1680261 reaction equation
[F:1][C:2]([F:24])([F:23])[C:3]([C:9]1[CH:14]=[C:13]([CH3:15])[C:12]([S:16][CH2:17][C:18]([O:20]C)=[O:19])=[C:11]([CH3:22])[CH:10]=1)([OH:8])[C:4]([F:7])([F:6])[F:5].[OH-].[Na+].Cl>C(O)C>[F:24][C:2]([F:1])([F:23])[C:3]([C:9]1[CH:10]=[C:11]([CH3:22])[C:12]([S:16][CH2:17][C:18]([OH:20])=[O:19])=[C:13]([CH3:15])[CH:14]=1)([OH:8])[C:4]([F:7])([F:6])[F:5]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 12898549HCID 12898549, compound

Product 1

HCID 12898562HCID 12898562, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Combine methyl 2-[4-(hexafluoro-2-hydroxy-2-propyl)-2,6-dimethylphenylthio]acetate with 30 ml ethanol and 5 ml 1.0 N sodium hydroxide. Reflux 4 hours, add 5 ml 1.0 N HCl, and extract with ether. Dry, concentrate and recrystallize from ether-hexane to obtain 2-[4-(hexafluoro-2-hydroxy-2-propyl)-2,6-dimethylphenylthio]acetic acid, m.p. 133°-135° C.

Workup

  1. temperatureReflux 4 hours
  2. extractionextract with ether
  3. customDry
  4. concentrationconcentrate
  5. customrecrystallize from ether-hexane

Sources & evidence

ORD record
ord-2719710cf60647469e54702cc4202616
Source dataset
uspto-grants-1981_06
Patent number
US04272550

Reaction notes

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