Hydrochloric Acid → HCID 12640192, compound

HRID 1680456Notes

Reaction equation

HRID 1680456 reaction equation
[F:1][C:2]1[CH:18]=[CH:17][C:5]([CH2:6][NH:7][C:8]2[CH:9]=[CH:10][C:11]([C:14]([OH:16])=[O:15])=[N:12][CH:13]=2)=[CH:4][CH:3]=1.[ClH:19]>C(O)(=O)C>[ClH:19].[F:1][C:2]1[CH:18]=[CH:17][C:5]([CH2:6][NH:7][C:8]2[CH:9]=[CH:10][C:11]([C:14]([OH:16])=[O:15])=[N:12][CH:13]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 126401915-{[(4-Fluorophenyl)methyl]amino}pyridine-2-carboxylic acid

Product 1

HCID 12640192HCID 12640192, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

0.5 g of 5-(p-fluorobenzylamino)-pyridine-2-carboxylic acid are dissolved in 5 ml of warm acetic acid and dry hydrogen chloride is added until the solution is saturated. Thereupon, nitrogen is bubbled into the solution for several minutes, the solid formed is collected and washed with diethyl ether to yield the 5-(p-fluorobenzylamino)-pyridine-2-carboxylic acid hydrochloride melting at 248°-253° with decomposition.

Workup

  1. customThereupon, nitrogen is bubbled into the solution for several minutes
  2. customthe solid formed
  3. customis collected
  4. washwashed with diethyl ether

Sources & evidence

ORD record
ord-347ece8527764fbfaf96909b43c334fb
Source dataset
uspto-grants-1981_06
Patent number
US04273779

Reaction notes

Loading…