Hydrochloric Acid → HCID 70565487, compound

HRID 1680578Notes

Reaction equation

HRID 1680578 reaction equation
C([NH:8][C@H:9]([C:18]([NH:20][C@@H:21]([C:26]([NH:28][CH2:29][C:30]([NH:32][C@H:33]([C:41]([CH:43]1[C:50]2([NH2:52])[CH2:51][CH:46]3[CH2:47][CH:48]([CH2:53][C:44]1([C:54]([NH2:56])=[O:55])[CH2:45]3)[CH2:49]2)=[O:42])[CH2:34][C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1)=[O:31])=[O:27])[CH2:22][CH2:23][S:24][CH3:25])=[O:19])[CH2:10][C:11]1[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][CH:12]=1)(OC(C)(C)C)=O.[ClH:57]>C(O)(=O)C.O1CCOCC1>[ClH:57].[NH2:8][C@H:9]([C:18]([NH:20][C@@H:21]([C:26]([NH:28][CH2:29][C:30]([NH:32][C@H:33]([C:41]([CH:43]1[C:50]2([NH2:52])[CH2:51][CH:46]3[CH2:47][CH:48]([CH2:53][C:44]1([C:54]([NH2:56])=[O:55])[CH2:45]3)[CH2:49]2)=[O:42])[CH2:34][C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1)=[O:31])=[O:27])[CH2:22][CH2:23][S:24][CH3:25])=[O:19])[CH2:10][C:11]1[CH:12]=[CH:13][C:14]([OH:17])=[CH:15][CH:16]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 70568198HCID 70568198, compound

Product 1

HCID 70565487HCID 70565487, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of 1.0 g of Boc-L-tyrosyl-D-methionyl-glycyl-L-phenylalanyl-3-amino-1-adamantanecarboxamide in 5.0 ml of glacial acetic acid is added 5.0 ml of a 6 N solution of hydrogen chloride in dioxane. The reaction mixture is stirred for 20 minutes at room temperature. The solvent is removed under reduced pressure, and the residue is dissolved in 125 ml of water. The solution is lyophilized to give L-tyrosyl-D-methionyl-glycyl-L-phenylalanyl-3-amino-1-adamantanecarboxamide hydrochloride which is represented by the following formula ##STR29##

Workup

  1. customThe solvent is removed under reduced pressure
  2. dissolutionthe residue is dissolved in 125 ml of water

Sources & evidence

ORD record
ord-12cf79d04f59496dae4096b652da9e18
Source dataset
uspto-grants-1981_06
Patent number
US04273704

Reaction notes

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