Hydrochloric Acid → HCID 86737807, compound

HRID 1680587Notes

Reaction equation

HRID 1680587 reaction equation
[C:1]([NH:8][C@@H:9]([C:11]([NH:13][CH2:14][C:15]([O:17]C)=[O:16])=[O:12])[CH3:10])(OC(C)(C)C)=O.[ClH:19]>C(O)(=O)C.O1CCOCC1>[ClH:19].[CH3:1][NH:8][C@@H:9]([C:11]([NH:13][CH2:14][C:15]([OH:17])=[O:16])=[O:12])[CH3:10]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 14158798HCID 14158798, compound

Product 1

HCID 86737807HCID 86737807, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

26.0 Grams of methyl Boc-D-alanylglycinate is dissolved in 340 ml of acetic acid, and 170 ml of a 6 N solution of hydrogen chloride in dioxane is added to the solution. The reaction mixture is allowed to stand for ten minutes and then the solvent is removed under vacuum. The residue is triturated with diethyl ether. The resulting white precipitate is filtered and washed with diethyl ether to afford methyl-D-alanylglycinate hydrochloride.

Workup

  1. waitto stand for ten minutes
  2. customthe solvent is removed under vacuum
  3. customThe residue is triturated with diethyl ether
  4. filtrationThe resulting white precipitate is filtered
  5. washwashed with diethyl ether

Sources & evidence

ORD record
ord-7e8b1d35c45542e5be8db64067871106
Source dataset
uspto-grants-1981_06
Patent number
US04273704

Reaction notes

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