Potassium Hydroxide → HCID 15714341, compound

HRID 1681117Notes

Reaction equation

HRID 1681117 reaction equation
[OH-].[K+].[OH:3][C:4]1[C:9]2[C:10]([CH3:15])=[CH:11][C:12](=[O:14])[O:13][C:8]=2[CH:7]=[CH:6][CH:5]=1.[CH3:16][N:17]([CH3:21])[C:18](Cl)=[S:19]>O.CC(C)=O>[CH3:16][N:17]([CH3:21])[C:18](=[S:19])[O:3][C:4]1[C:9]2[C:10]([CH3:15])=[CH:11][C:12](=[O:14])[O:13][C:8]=2[CH:7]=[CH:6][CH:5]=1

Participants

6

Reactant 3

HCID 14797Potassium HydroxideHCID 27871Dimethylthiocarbamoyl chlorideHCID 53575445-hydroxy-4-methyl-2H-1-benzopyran-2-one

Product 1

HCID 15714341HCID 15714341, compoundYield 90.3%

Reagents, catalysts & solvents 2

HCID 180AcetoneSolvent2×HCID 962WaterSolvent

Procedure

410 mg (7.3.10-3 mol) of potassium hydroxide are added under an inert atmosphere to a suspension of 1 g (5.7.10-3 mol) of 5-hydroxy-4-methyl-2H-1-benzopyran-2-one in 10 ml of water and 10 ml of acetone. After 10 minutes at room temperature, 770 mg (6.2.10-3 mol) of dimethylthiocarbamoyl chloride in 10 ml of acetone are added at 0° C. The reaction mixture is stirred for 2 hours at room temperature and then, after evaporation of the acetone, the expected derivative is precipitated in water to give 1.35 g (yield: 90%) of the expected product.

Workup

  1. customafter evaporation of the acetone
  2. customthe expected derivative is precipitated in water

Sources & evidence

ORD record
ord-8e72b01c20a842768620706666d73fae
Source dataset
uspto-grants-1992_12
Patent number
US05169838

Reaction notes

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