Formaldehyde → HCID 14425093, compound

HRID 1681128Notes

Reaction equation

HRID 1681128 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][CH:7]([C:12]([O-])=O)[C:8]([O:10][CH3:11])=[O:9].C(NCC)C.C=O>>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][C:7](=[CH2:12])[C:8]([O:10][CH3:11])=[O:9]

Participants

4

Reactant 3

HCID 712FormaldehydeHCID 8021DiethylamineHCID 198071623-Methoxy-3-oxo-2-[(thiophen-2-yl)methyl]propanoate

Product 1

HCID 14425093HCID 14425093, compoundYield 75.4%

Procedure

11.8 g of monomethyl 2-thienylmethylmalonate, 5.8 ml of diethylamine and 5.0 ml of 36% aqueous formaldehyde solution are stirred under argon at R.T. for 1 h. The water is subsequently removed in vacuo, and the residue is chromatographed. 7.6 g of the title compound are obtained as a colorless liquid.

Workup

  1. customThe water is subsequently removed in vacuo
  2. customthe residue is chromatographed

Sources & evidence

ORD record
ord-7abc50ab21a3441bb96b2f9370d01135
Source dataset
uspto-grants-1992_12
Patent number
US05169841

Reaction notes

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