Benzaldehyde → 5,5-Dimethyl-2-phenyl-1,3-thiazolidine-4-carboxylic acid

HRID 1681157Notes

Reaction equation

HRID 1681157 reaction equation
[CH:1](=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:9][C@H:10]([C:15]([OH:17])=[O:16])[C:11]([SH:14])([CH3:13])[CH3:12]>C(O)C.O>[CH3:12][C:11]1([CH3:13])[S:14][CH:1]([C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[NH:9][CH:10]1[C:15]([OH:17])=[O:16]

Participants

5

Reactant 2

HCID 240BenzaldehydeHCID 92863L-Penicillamine

Product 1

HCID 419475,5-Dimethyl-2-phenyl-1,3-thiazolidine-4-carboxylic acid

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

One mole of benzaldehyde was dissolved in 100 cc of 90% ethanol with continuous stirring. One mole of penicillamine was dissolved in water with continuous stirring. The two solutions were then mixed together while stirring was continued. The solution was left to stand at room temperature. Within 15 minutes, a white precipitate occurred. The white precipitate was washed with distilled water through sintered glass. The washed precipitate was then dryed at 100° C. to obtain crystals.

Workup

  1. additionThe two solutions were then mixed together
  2. waitThe solution was left
  3. customto stand at room temperature
  4. washThe white precipitate was washed with distilled water through sintered glass
  5. customwas then dryed at 100° C.
  6. customto obtain crystals

Sources & evidence

ORD record
ord-b4e6c42e1d1f492cb240c1c87439436c
Source dataset
uspto-grants-1992_12
Patent number
US05169858

Reaction notes

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