Trifluoroacetic acid → HCID 141560929, compound

HRID 1681165Notes

Reaction equation

HRID 1681165 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5](/[C:7](=[N:46]/[O:47][CH3:48])/[C:8]([NH:10][CH:11]2[C:44](=[O:45])[N:13]3[C:14]([C:28]([O:30]C(C4C=CC=CC=4)C4C=CC=CC=4)=[O:29])=[C:15]([C:18]4[C:21](=[O:22])[C:20](=[O:23])[C:19]=4[O:24][CH:25]([CH3:27])[CH3:26])[CH2:16][S:17][C@H:12]23)=[O:9])[N:6]=1.FC(F)(F)C(O)=O>C1(OC)C=CC=CC=1>[NH2:1][C:2]1[S:3][CH:4]=[C:5](/[C:7](=[N:46]/[O:47][CH3:48])/[C:8]([NH:10][CH:11]2[C:44](=[O:45])[N:13]3[C:14]([C:28]([OH:30])=[O:29])=[C:15]([C:18]4[C:21](=[O:22])[C:20](=[O:23])[C:19]=4[O:24][CH:25]([CH3:27])[CH3:26])[CH2:16][S:17][C@H:12]23)=[O:9])[N:6]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 141560921HCID 141560921, compound

Product 1

HCID 141560929HCID 141560929, compound

Reagents, catalysts & solvents 1

HCID 7519AnisoleSolvent

Procedure

Diphenylmethyl 7-[2-(2-aminothiazol-4-yl)-(Z)-2-methoxyiminoacetamido]-3-[3,4-dioxo-2-(2-propoxy)-1-cyclobutenyl]-3-cephem-4-carboxylate (33 mg) was added to a stirred, cooled (ice/H2O bath) solution of trifluoroacetic acid (100 μL) and anisole (50 μL). The cooling bath was removed, and stirring was continued for 1 hr at ambient temperatures. The solution was diluted with diethyl ether to precipitate the trifluoroacetic acid salt of the title compound as a yellow powder.

Workup

  1. customThe cooling bath was removed
  2. additionThe solution was diluted with diethyl ether
  3. customto precipitate the trifluoroacetic acid salt of the title compound as a yellow powder

Sources & evidence

ORD record
ord-20ad93b7fd2c4f8fb52fe19109571f94
Source dataset
uspto-grants-1992_12
Patent number
US05169843

Reaction notes

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