Hydrochloric Acid → 143347-15-3

HRID 1681217Notes

Reaction equation

HRID 1681217 reaction equation
Br[CH:2]([CH3:4])[CH3:3].[CH3:5][NH:6][CH2:7][C:8]#[CH:9].[ClH:10]>C(O)C>[ClH:10].[CH3:3][CH:2]([N:6]([CH2:7][C:8]#[CH:9])[CH3:5])[CH3:4]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 63582-BromopropaneHCID 96160N-methylpropyn-2-ylamine

Product 1

HCID 15986125143347-15-3Yield 16%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-Bromopropane (3.08 g, 25 mmoles) and N-methylpropargylamine (3.45 g, 50 mmoles) in absolute ethanol (50 mL) were heated at reflux for 48 h. On treatment of the ethereal solution of the free base with ethanolic hydrochloride acid, an oil first separated, and then white needles subsequently precipitated very slowly from the supernatant (16% yield of white needles, recrystallized from methanol-ether), m.p.=155°-156° C. The oil and the needles gave identical mass spectra.

Workup

  1. temperatureat reflux for 48 h

Sources & evidence

ORD record
ord-d9be6697f9b24692a5f4cc1752fde11c
Source dataset
uspto-grants-1992_12
Patent number
US05169868

Reaction notes

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