Salicylaldehyde → HCID 136403409, compound

HRID 1681221Notes

Reaction equation

HRID 1681221 reaction equation
[OH-].[Na+].[CH:3](=O)[C:4]1[C:5](=[CH:7][CH:8]=[CH:9][CH:10]=1)[OH:6].[ClH:12].Cl.[O:14]([CH2:16][CH:17]([F:21])[CH2:18][NH:19][CH3:20])[NH2:15]>C(O)C>[ClH:12].[OH:6][C:5]1[CH:7]=[CH:8][CH:9]=[CH:10][C:4]=1[CH:3]=[N:15][O:14][CH2:16][CH:17]([F:21])[CH2:18][NH:19][CH3:20]

Participants

5

Reactant 3

HCID 6998SalicylaldehydeHCID 14798Sodium HydroxideHCID 19807375HCID 19807375, compound

Product 1

HCID 136403409HCID 136403409, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2.5 ml of 1N sodium hydroxide solution and 305 mg (2.5 mmol) of salicylaldehyde are added to a solution of 488 mg (2.5 mmol) of N-(3-aminoxy-2-fluoropropyl)-methylamine dihydrochloride in 10 ml of ethanol and the mixture is stirred for 24 hours at room temperature. The reaction mixture is then concentrated to dryness by evaporation and the residue is crystallised from ethanol/ether.

Workup

  1. concentrationThe reaction mixture is then concentrated to dryness by evaporation
  2. customthe residue is crystallised from ethanol/ether

Sources & evidence

ORD record
ord-b41e1e50795c451bbf8a5fb062f1abbf
Source dataset
uspto-grants-1992_12
Patent number
US05169867

Reaction notes

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