Acetic Acid → HCID 54038256, compound

HRID 1681261Notes

Reaction equation

HRID 1681261 reaction equation
[F:1][C:2]1[CH:15]=[CH:14][C:5]([C:6]([CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])=O)=[CH:4][CH:3]=1.[CH3:16][CH:17]([CH3:20])[CH:18]=O.N1CCCCC1.C(O)(=O)C>C(O)(C)C>[F:1][C:2]1[CH:15]=[CH:14][C:5]([CH2:6][C:8](=[CH:16][CH:17]([CH3:20])[CH3:18])[C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:4][CH:3]=1

Participants

6

Reactant 4

HCID 176Acetic AcidHCID 6561IsobutyraldehydeHCID 8082PiperidineHCID 2758844Ethyl 3-(4-Fluorophenyl)-3-Oxopropanoate

Product 1

HCID 54038256HCID 54038256, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

A solution of 210 g (1 mmol) of ethyl 4-fluorobenzoylacetate and 144 g (2 mol) of 2-methylpropanal are stirred overnight at 50° C. with 7 ml of piperidine and 5 ml of acetic acid in 100 ml of isopropanol. After reaction is complete, the batch is concentrated at about 15 Torr and the crude product (270 g, about 85%) is reacted without further purification.

Workup

  1. customAfter reaction
  2. concentrationthe batch is concentrated at about 15 Torr
  3. customthe crude product (270 g, about 85%) is reacted without further purification

Sources & evidence

ORD record
ord-b26ecca92d3e448a96c4f39f3aeaf14e
Source dataset
uspto-grants-1992_12
Patent number
US05169857

Reaction notes

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