Triethylamine → Benzoic acid, 4-(phenylmethoxy)-, 1-(trifluoromethyl)heptyl ester

HRID 1681314Notes

Reaction equation

HRID 1681314 reaction equation
[CH2:1]([O:8][C:9]1[CH:17]=[CH:16][C:12]([C:13](Cl)=[O:14])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CN(C1C=CC=CN=1)C.C(N(CC)CC)C.[F:34][C:35]([F:45])([F:44])[CH:36]([OH:43])[CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH3:42]>C(Cl)Cl>[CH2:1]([O:8][C:9]1[CH:17]=[CH:16][C:12]([C:13]([O:43][CH:36]([C:35]([F:34])([F:44])[F:45])[CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH3:42])=[O:14])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 218852-DimethylaminopyridineHCID 978042-Octanol, 1,1,1-trifluoro-HCID 37664104-Benzyloxybenzoylchloride

Product 1

HCID 14549213Benzoic acid, 4-(phenylmethoxy)-, 1-(trifluoromethyl)heptyl ester

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

4-Benzyloxy-benzoic acid chloride in an amount of 4.3 g was dissolved in 50 ml of methylene chloride, to which a solution of 2.9 g of optically active 1,1,1-trifluoro-2-octanol, 0.6 g of dimethylaminopyridine and 1.7 g of triethylamine in 50 ml of methlene chloride was gradually added under cooling with ice.

Workup

  1. additionwas gradually added
  2. temperatureunder cooling with ice

Sources & evidence

ORD record
ord-941b1beda29e4e81b66d34d17358aef7
Source dataset
uspto-grants-1992_12
Patent number
US05171471

Reaction notes

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