Trifluoroacetic acid → HCID 131717676, compound

HRID 1681323Notes

Reaction equation

HRID 1681323 reaction equation
[C:1]([O:4][C:5](C(C)(C)C)(C(C)(C)C)[CH2:6][O:7][CH2:8][CH2:9][O:10][CH2:11][CH2:12][O:13]C(=O)C)(=[O:3])[CH3:2].F[C:26](F)(F)[C:27]([OH:29])=[O:28]>>[CH2:5]([OH:4])[CH2:6][O:7][CH2:8][CH2:9][O:10][CH2:11][CH2:12][OH:13].[CH3:2][C:1]([CH2:26][C:27]([OH:29])=[O:28])=[O:3]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 131717677HCID 131717677, compound

Product 1

HCID 131717676HCID 131717676, compound

Procedure

18.9 g. (50 mMole) of the ester (2) are dissolved at ambient temperature in 30 ml. trifluoroacetic acid and stirred for 2 hours. The solution is evaporated at 35° C. under water pump vacuum, the residue is digested three times with, in each case, 100 ml. diethyl ether and dried in a high vacuum at 45° C. The product (3) can be further used without further purification. Yield: 11.2 g. of colourless oil; 84% of theory.

Workup

  1. customThe solution is evaporated at 35° C. under water pump vacuum
  2. dry with materialdiethyl ether and dried in a high vacuum at 45° C
  3. customThe product (3) can be further used without further purification

Sources & evidence

ORD record
ord-26a7b784a9c44ac9b76f54da1726b0bd
Source dataset
uspto-grants-1992_12
Patent number
US05171679

Reaction notes

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