Hydrogen Peroxide → HCID 22394127, compound

HRID 1681332Notes

Reaction equation

HRID 1681332 reaction equation
[CH2:1]([O:3][CH2:4][CH2:5][S:6][C:7]1[S:8][CH:9]=[C:10]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)[N:11]=1)[CH3:2].OO.C(=O)([O-])[OH:21].[Na+]>C(O)(=O)C.O.[O-][W]([O-])(=O)=O.[Na+].[Na+]>[CH2:1]([O:3][CH2:4][CH2:5][S:6]([C:7]1[S:8][CH:9]=[C:10]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)[N:11]=1)=[O:21])[CH3:2]

Participants

7

Reactant 3

HCID 784Hydrogen PeroxideHCID 516892Sodium BicarbonateHCID 19806348HCID 19806348, compound

Product 1

HCID 22394127HCID 22394127, compoundYield 77%

Reagents, catalysts & solvents 3

HCID 26052Sodium tungstateCatalystHCID 176Acetic AcidSolventHCID 962WaterSolvent

Procedure

Dissolved in 1.7 ml of acetic acid were 0.33 g (1.24 mmol) of the compound obtained in Example 1, and 0.15 ml (1.32 mmol) of a 30% aqueous solution of hydrogen peroxide and a catalytic amount of sodium tungstate were successively added to the solution, which was stirred at room temperature for 4 hours. The reaction solution was poured in 34 ml of water, neutralized with sodium hydrogencarbonate and extracted with 34 ml of chloroform. After separation of the chloroform layer, the organic layer was dried over anhydrous magnesium sulfate and concentrated in vacuo. The residues were purified by silica gel chromatography to obtain 0.27 g of white crystalline powders (77% yield).

Workup

  1. extractionextracted with 34 ml of chloroform
  2. customAfter separation of the chloroform layer
  3. dry with materialthe organic layer was dried over anhydrous magnesium sulfate
  4. concentrationconcentrated in vacuo
  5. customThe residues were purified by silica gel chromatography

Sources & evidence

ORD record
ord-5299d1424a784cd28d80e0db2dab82ed
Source dataset
uspto-grants-1992_12
Patent number
US05171746

Reaction notes

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