1,2-Epoxybutane → HCID 19806492, compound

HRID 1681379Notes

Reaction equation

HRID 1681379 reaction equation
[NH2:1][C:2]([CH3:6])([CH3:5])[CH2:3][OH:4].[CH2:7]1[O:11][CH:8]1[CH2:9][CH3:10]>O>[OH:11][CH:8]([CH2:9][CH3:10])[CH2:7][NH:1][C:2]([CH3:6])([CH3:5])[CH2:3][OH:4]

Participants

4

Reactant 2

HCID 78341,2-EpoxybutaneHCID 118072-Amino-2-methyl-1-propanol

Product 1

HCID 19806492HCID 19806492, compoundYield 82%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

In this example, 1780 g (20 mol) of 2-amino-2-methyl-1-propanol and 10 g water were added to a 5-liter three-necked flask equipped with a thermometer, condenser, magnetic stirrer, dropping funnel, and nitrogen inlet. 1,2-butylene oxide (1584 g, 22 mol) was added into the flask slowly at 90° C.-100° C. with stirring and under a nitrogen atmosphere. The resulting crude product was N-(2'-hydroxybutyl)-2-amino-2-methyl-1-propanol (82% yield with 90% alkanolamine conversion as determined by GLC).

Workup

  1. customequipped with a thermometer, condenser, magnetic stirrer

Sources & evidence

ORD record
ord-659e357842db4b148b85b8ec02613713
Source dataset
uspto-grants-1992_12
Patent number
US05171819

Reaction notes

Loading…