Iodine chloride → HCID 19806575, compound

HRID 1681389Notes

Reaction equation

HRID 1681389 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:12]=[C:11]([CH3:13])[N:10]=[CH:9]2)=[CH:4][C:3]=1[CH3:14].[I:15]Cl.C(=O)(O)[O-].[Na+]>C(O)(=O)C>[NH2:1][C:2]1[C:7]([I:15])=[CH:6][C:5]([N:8]2[CH:12]=[C:11]([CH3:13])[N:10]=[CH:9]2)=[CH:4][C:3]=1[CH3:14]

Participants

5

Reactant 3

HCID 24640Iodine chlorideHCID 516892Sodium BicarbonateHCID 14450266HCID 14450266, compound

Product 1

HCID 19806575HCID 19806575, compoundYield 41%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of 2-amino-5-(4-methylimidazol-1-yl)toluene (100 mg), iodomono-chloride (104 mg) and acetic acid (1.3 ml) was stirred at room temperature for 2 hours. Solvent was removed under reduced pressure to give a residue. The residue was made to pH 10 with saturated sodium bicarbonate solution, extracted with chloroform. The extract was dried with MgSO4, filtered and removed solvent to give 68 mg (41%) of the title compound.

Workup

  1. customSolvent was removed under reduced pressure
  2. customto give a residue
  3. extractionextracted with chloroform
  4. dry with materialThe extract was dried with MgSO4
  5. filtrationfiltered
  6. customremoved solvent

Sources & evidence

ORD record
ord-b44e028563cb44de878a61f1c0d2ee7a
Source dataset
uspto-grants-1992_12
Patent number
US05171851

Reaction notes

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