HCID 19803857, compound → HCID 67918206, compound

HRID 1682007Notes

Reaction equation

HRID 1682007 reaction equation
[Br-:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]([CH2:12][CH2:13][N+:14]2[CH:19]=[CH:18][CH:17]=[C:16]([CH2:20][N:21]3[C:27](=[O:28])[CH2:26][C:25]4[CH:29]=[C:30]([O:35][CH3:36])[C:31]([O:33][CH3:34])=[CH:32][C:24]=4[CH:23]=[CH:22]3)[CH:15]=2)[CH:7]=[CH:8][C:9]=1[O:10][CH3:11]>CO.[Pt](=O)=O>[BrH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]([CH2:12][CH2:13][N:14]2[CH2:19][CH2:18][CH2:17][CH:16]([CH2:20][N:21]3[C:27](=[O:28])[CH2:26][C:25]4[CH:29]=[C:30]([O:35][CH3:36])[C:31]([O:33][CH3:34])=[CH:32][C:24]=4[CH2:23][CH2:22]3)[CH2:15]2)[CH:7]=[CH:8][C:9]=1[O:10][CH3:11]

Participants

4

Reactant 1

HCID 19803857HCID 19803857, compound

Product 1

HCID 67918206HCID 67918206, compound

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 887MethanolSolvent

Procedure

3.7 g (0.0067 mol) of 3-[(N-(2-(3,4-dimethoxy-phenyl)ethyl)-pyridinium-3-yl)-methyl]7, 8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one-bromide are hydrogenated in 70 ml of methanol in the presence of 0.7 g of platinum dioxide for 3 hours at ambient temperature and under 5 bar. The catalyst is removed by suction filtering, the methanol is distilled off in vacuo and the residue is dissolved in a little methanol and mixed with acetone. The precipitate is suction filtered and dried.

Workup

  1. customThe catalyst is removed by suction
  2. filtrationfiltering
  3. distillationthe methanol is distilled off in vacuo
  4. dissolutionthe residue is dissolved in a little methanol
  5. additionmixed with acetone
  6. filtrationfiltered
  7. customdried

Sources & evidence

ORD record
ord-9077174fd4664b53a8caca0da85c242b
Source dataset
uspto-grants-1992_12
Patent number
US05175157

Reaction notes

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