Ammonium formate → HCID 67689997, compound

HRID 1682103Notes

Reaction equation

HRID 1682103 reaction equation
[K:1].[NH2:2][C:3]1[N:11]=[C:10]2[C:6]([N:7]=[CH:8][N:9]2[CH2:12][CH2:13][CH:14]2[C:19](=[O:20])[O:18][C:17]([CH3:22])([CH3:21])[O:16][C:15]2=[O:23])=[C:5](Cl)[N:4]=1.C([O-])=O.[NH4+].C(Cl)(Cl)Cl.CO>CO>[K:1].[NH2:2][C:3]1[N:11]=[C:10]2[C:6]([N:7]=[CH:8][N:9]2[CH2:12][CH2:13][CH:14]2[C:19](=[O:20])[O:18][C:17]([CH3:21])([CH3:22])[O:16][C:15]2=[O:23])=[CH:5][N:4]=1

Participants

5

Reactant 3

HCID 2723923Ammonium formateHCID 21584188Chloroform methanolHCID 86746437HCID 86746437, compound

Product 1

HCID 67689997HCID 67689997, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 2-amino-6-Chloro-9-[1-(2,2-dimethyl-1,3-dioxane-4,6-dione-5-yl)eth-2-yl]purine potassium salt (200 mg, 0.53 mmol), ammonium formate (148 mg, 2.34 mmol) and 10% palladuim on charcoal (80 mg) in methanol (15 ml) was heated under reflux under dry nitrogen for 3 h. T.1.c. [chloroform/methanol (2:1)] showed one spot, rf=0.15. The mixture was filtered and the filtrate evaporated to leave a gum. The material was not purified further.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux under dry nitrogen for 3 h
  3. filtrationThe mixture was filtered
  4. customthe filtrate evaporated
  5. customto leave a gum
  6. customThe material was not purified further

Sources & evidence

ORD record
ord-d05a82faff354ee7ba48e7386fb3ec91
Source dataset
uspto-grants-1992_12
Patent number
US05175288

Reaction notes

Loading…