反应详情

51 g (0.6 mole) of cyanoacetic acid, 74 g (0.84 mole) of neopentyl alcohol, 1 g of sulfuric acid and 100 g of toluene were reacted under reflux and water produced was removed by azeotropic distillation. Thereafter, the mixture thus produced was cooled to a room temperature and filtered to remove insoluble matter. The filtrate was washed with water and dried overnight with magensium sulfate. Then, the desiccant was filtered off and the solvent was removed under a reduced pressure, followed by vacuum distillation to afford 87.1 g of neopentyl α-cyanoacrylate (b.p. 79°-81° C./ 3 mmHg, yield 94%).

1. temperatureunder reflux
2. customwas removed by azeotropic distillation
3. customThereafter, the mixture thus produced
4. filtrationfiltered
5. customto remove insoluble matter
6. washThe filtrate was washed with water
7. dry with materialdried overnight with magensium sulfate
8. filtrationThen, the desiccant was filtered off
9. customthe solvent was removed under a reduced pressure
10. distillationfollowed by vacuum distillation