反应详情

2.0 g of E-2-amino-4-methyl-5-phosphono-3-pentenoic acid are placed in 50 ml of ethanol and the whole is saturated with hydrogen chloride gas for 21/2 hours at 50°. After concentration, the residue is dissolved in 20 ml of ethanol, 20 ml of propylene oxide are added and the precipitate is filtered off. Recrystallisation from water/ethanol (1:3) yields E-2-amino-4-methyl-5-phosphono-3-pentenoic acid ethyl ester, m.p. 193°-194°.

1. custom2 hours
2. customat 50°
3. concentrationAfter concentration
4. dissolutionthe residue is dissolved in 20 ml of ethanol
5. addition20 ml of propylene oxide are added
6. filtrationthe precipitate is filtered off
7. customRecrystallisation from water/ethanol (1:3)