Hydrochloric Acid → HCID 19804964, compound

HRID 1682288Notes

Reaction equation

C([O:3][C:4](=[O:21])[CH:5]([NH:18]C=O)/[CH:6]=[CH:7]/[CH:8]([P:10]([O:15]CC)([O:12]CC)=[O:11])[CH3:9])C.Cl>>[NH2:18][CH:5](/[CH:6]=[CH:7]/[CH:8]([CH3:9])[P:10]([OH:15])([OH:12])=[O:11])[C:4]([OH:21])=[O:3]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 23181461HCID 23181461, compound

Product 1

HCID 19804964HCID 19804964, compound

Procedure

E-2-formylamino-5-diethylphosphono-5-methyl-3-pentenoic acid ethyl ester is hydrolysed with 4.35 N hydrochloric acid in the manner described in Example 11. E-2-amino-5-methyl-5-phosphono-3-pentenoic acid is isolated in the form of an amorphous white solid mass. 1H-NMR (D2O) 1.05 (dd, 3H, CH3); 2.45 (m, 1H, C(5)-H); 4.33 (d, 2H, C(2)-H); 5.5 and 5.9 (2m, 2H, C(3)-H and C(4)-H).

Sources & evidence

ORD record: ord-c7d35947d7ac45aeb4ffe8da3053937d
Source dataset: uspto-grants-1992_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05175344

Reaction notes

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