Hydrochloric Acid → 4-Cyano-4-(pyridin-3-yl)-piperidine hydrochloride

HRID 1683003Notes

Reaction equation

HRID 1683003 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][C:11]([C:20]#[N:21])([C:14]2[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:22].O1CCOCC1>>[ClH:22].[C:20]([C:11]1([C:14]2[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=2)[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)#[N:21]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 53793625tert-Butyl 4-cyano-4-(pyridin-3-yl)piperidine-1-carboxylate

Product 1

HCID 533632724-Cyano-4-(pyridin-3-yl)-piperidine hydrochloride

Procedure

Prepare by the method of example 30.3 using 1-tert-butoxycarbonyl-4-cyano-4-(pyridin-3-yl)-piperidine (3 mmol) and HCl in dioxane (40 mmol, 4N). Concentrate the solvent in vacuo and dry under high vacuum to give the title compound.

Workup

  1. concentrationConcentrate the solvent in vacuo
  2. customdry under high vacuum

Sources & evidence

ORD record
ord-2520bb6dcbc7418eaaee1123017f9c00
Source dataset
uspto-grants-1997_06
Patent number
US05635510

Reaction notes

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