反应详情

Combine 3-hydroxybenzoic acid (100 mmol), 2-iodopropane (500 mmol), K2CO3 (300 mmol), and 2-butanone (300 mL). Heat at reflux for 72 h. Concentrate in vacuo to obtain a residue. Add water (500 mL) and cool in an ice bath. Adjust to pH 1 by dropwise addition of concentrated HCl. Extract with dichloromethane (3×200 mL). Extract the combined organic layers with water (200 mL), dry over Na2SO4, filter, and concentrate in vacuo to obtain a residue. Purify to obtain the title compound.

1. temperatureHeat
2. temperatureat reflux for 72 h
3. concentrationConcentrate in vacuo
4. customto obtain a residue
5. extractionExtract with dichloromethane (3×200 mL)
6. extractionExtract the combined organic layers with water (200 mL)
7. dry with materialdry over Na2SO4
8. filtrationfilter
9. concentrationconcentrate in vacuo
10. customto obtain a residue
11. customPurify