Hydrochloric Acid → N4-[2-(5-chloro-2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-pyrimidine-2,4-diamine

HRID 168351Notes

Reaction equation

HRID 168351 reaction equation
[C:1]([O:2][C:3](=[O:4])[NH:7][c:8]1[n:9][cH:10][cH:11][c:12]([NH:14][c:15]2[cH:16][c:17](-[c:25]3[c:26]([F:32])[cH:27][cH:28][c:29]([Cl:31])[cH:30]3)[n:18][c:19]3[n:20][cH:21][cH:22][cH:23][c:24]23)[n:13]1)([CH3:5])([CH3:6])[CH3:33].[ClH:34].[O:35]1[CH2:36][CH2:37][O:38][CH2:39][CH2:40]1>>[NH2:7][c:8]1[n:9][cH:10][cH:11][c:12]([NH:14][c:15]2[cH:16][c:17](-[c:25]3[c:26]([F:32])[cH:27][cH:28][c:29]([Cl:31])[cH:30]3)[n:18][c:19]3[n:20][cH:21][cH:22][cH:23][c:24]23)[n:13]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 53372717{4-[2-(5-Chloro-2-fluoro-phenyl)-[1,8]naphthyridin-4-ylamino]-pyrimidin-2-yl}-carbamic acid tert-butyl ester

Product 1

HCID 53372718N4-[2-(5-chloro-2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-pyrimidine-2,4-diamine

Sources & evidence

ORD record
ord-8eeff0af827749a9b7de1755135ff796
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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