Bromopinacolone → HCID 2851567, compound

HRID 1683727Notes

Reaction equation

HRID 1683727 reaction equation
[OH:1][CH2:2][CH2:3][NH:4][C:5]1[NH:6][C:7]2[CH:13]=[CH:12][CH:11]=[CH:10][C:8]=2[N:9]=1.[CH3:14][C:15]([C:18]([CH2:20][Br:21])=[O:19])([CH3:17])[CH3:16]>C(O)CC>[BrH:21].[OH:1][CH2:2][CH2:3][NH:4][C:5]1[N:6]([CH2:20][C:18](=[O:19])[C:15]([CH3:17])([CH3:16])[CH3:14])[C:7]2[CH:13]=[CH:12][CH:11]=[CH:10][C:8]=2[N:9]=1

Participants

4

Reactant 2

HCID 21642BromopinacoloneHCID 5838672-((1H-1,3-benzodiazol-2-yl)amino)ethan-1-ol

Product 1

HCID 2851567HCID 2851567, compound

Reagents, catalysts & solvents 1

HCID 10311-PropanolSolvent

Procedure

Heat at reflux for 3 hours a mixture of 2-(2-hydroxyethylamino)benzimidazole (1.77 g, 10 mmol) and bromopinacoline (1.35 g, 10 mmol) in 50 ml of propanol. Subsequently maintain at room temperature. The next day, the title compound is collected by filtration and washed with acetone and then with ether.

Workup

  1. temperatureHeat
  2. temperatureat reflux for 3 hours
  3. filtrationThe next day, the title compound is collected by filtration
  4. washwashed with acetone

Sources & evidence

ORD record
ord-ab2d8f01f98348bd9b410527648cab5a
Source dataset
uspto-grants-1997_06
Patent number
US05639756

Reaction notes

Loading…