1-Bromo-3-chloropropane → HCID 19040845, compound

HRID 1683731Notes

Reaction equation

HRID 1683731 reaction equation
[CH2:1]([N:3]([CH2:16][CH3:17])[CH2:4][CH2:5][NH:6][C:7]1[NH:8][C:9]2[CH:15]=[CH:14][CH:13]=[CH:12][C:10]=2[N:11]=1)[CH3:2].Br[CH2:19][CH2:20][CH2:21]Cl>C1(C)C(C)=CC=CC=1>[CH2:16]([N:3]([CH2:1][CH3:2])[CH2:4][CH2:5][N:6]1[C:7]2=[N:8][C:9]3[CH:15]=[CH:14][CH:13]=[CH:12][C:10]=3[N:11]2[CH2:21][CH2:20][CH2:19]1)[CH3:17]

Participants

4

Reactant 2

HCID 80061-Bromo-3-chloropropaneHCID 1503634HCID 1503634, compound

Product 1

HCID 19040845HCID 19040845, compound

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

Heat at reflux for 12 hours a mixture of 1.16 g (5 mmol) of 2-(2-diethylaminoethylamino) benzimidazole and 0.6 ml (5 mmol) of 1-bromo-3-chloropropane in 10 ml of xylene. After cooling, the xylene is decanted off and the residual oil is treated with petroleum ether. Evaporate the remaining petroleum ether and treat with ammonium hydroxide. Extract with chloroform. The combined organic phases are concentrated and passed over a column of alumina eluted with chloroform. The evaporation of the solvent allows the title compound to be obtained.

Workup

  1. temperatureHeat
  2. temperatureat reflux for 12 hours
  3. temperatureAfter cooling
  4. customthe xylene is decanted off
  5. additionthe residual oil is treated with petroleum ether
  6. customEvaporate the remaining petroleum ether
  7. additiontreat with ammonium hydroxide
  8. extractionExtract with chloroform
  9. concentrationThe combined organic phases are concentrated
  10. washeluted with chloroform
  11. customThe evaporation of the solvent
  12. customto be obtained

Sources & evidence

ORD record
ord-f2b2db73773141c9baa28e59b61ba93e
Source dataset
uspto-grants-1997_06
Patent number
US05639756

Reaction notes

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