反应详情

To the indole of Example 7, Step 1, (1.00 g, 4.29 mmol) in DMF (15.0 mL) at 0° C. were added NaH 60% in oil (188 mg, 4.72 mmol) and a solution of 4-chloromethylthioanisole (810 mg, 4.7 mmol) in DMF (5.0 mL). After a period of 5 min at r.t., the reaction was quenched by the addition of 25% aqueous solution of NH4OAc. The reaction was extracted with EtOAc, dried over Na2SO4, evaporated in vacuo and purified by flash chromatography (20% EtOAc in hexane) to provide the title compound (770 mg).

1. customthe reaction was quenched by the addition of 25% aqueous solution of NH4OAc
2. extractionThe reaction was extracted with EtOAc
3. dry with materialdried over Na2SO4
4. customevaporated in vacuo
5. custompurified by flash chromatography (20% EtOAc in hexane)