Diethyl Ether → 3-(N,N-diallylamino)-5-methoxychroman

HRID 1684073Notes

Reaction equation

HRID 1684073 reaction equation
Cl.[NH2:2][CH:3]1[CH2:12][C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[O:13][CH3:14])[O:5][CH2:4]1.[CH2:15](Br)[CH:16]=[CH2:17].C([O-])([O-])=O.[K+].[K+].[CH3:25][N:26]([CH:28]=O)[CH3:27].[CH3:30][CH2:31]OCC>>[CH2:17]([NH:2][CH:3]1[CH2:12][C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[O:13][CH3:14])[O:5][CH2:4]1)[CH:16]=[CH2:15].[CH2:28]([N:26]([CH:25]1[CH2:12][C:11]2[C:10](=[CH:9][CH:8]=[CH:7][C:6]=2[O:5][CH3:4])[O:13][CH2:14]1)[CH2:27][CH:16]=[CH2:17])[CH:30]=[CH2:31]

Participants

7

Reactant 5

HCID 3283Diethyl EtherHCID 6228DimethylformamideHCID 7841Allyl bromideHCID 11430Potassium CarbonateHCID 139289495-Methoxychroman-3-amine hydrochloride

Product 2

HCID 141036013-(N,N-diallylamino)-5-methoxychromanYield 56%HCID 141036023-(N-Allylamino)-5-methoxychromanYield 33%

Procedure

3-Amino-5-methoxychroman hydrochloride (Acta Pharm. Suec. 24 (1987) (5.0 g, 23 mmol), allyl bromide (3.4 mL, 39 mmol), anhydrous K2CO3 (9.6 g, 69 mmol) and DMF (8.0 mL) were stirred under N2 at room temperature for 72 hours. Ether (150 mL) was added, the salts were filtered off by suction and the clear filtrate was concentrated in vacuo. The residue was purified on a silica column eluted with 1000 mL THF-n-hexan (1:9) and 1000 mL THF-hexan (1:3) to afford 3-(N-allylamino)-5-methoxychroman (1.7 g; 33% yield) and 3-(N,N-diallylamino)-5-methoxychroman (3.4 g, 56% yield) as oils. The diallylamino derivative above was isolated as the hydrochloride salt by addition of a slight excess of HCl (approx. 3M in ether) to an ether solution of the amine. The crude HCl salt crystallized on standing, with ether, in the cold. Mp 139°-140° C.

Workup

  1. filtrationthe salts were filtered off by suction
  2. concentrationthe clear filtrate was concentrated in vacuo
  3. customThe residue was purified on a silica column
  4. washeluted with 1000 mL THF-n-hexan (1:9) and 1000 mL THF-hexan (1:3)

Sources & evidence

ORD record
ord-a7c890ba3fba475eae1ec35c6601b433
Source dataset
uspto-grants-1997_06
Patent number
US05639772

Reaction notes

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