HCID 14697649, compound → HCID 19039457, compound

HRID 1684516Notes

Reaction equation

HRID 1684516 reaction equation
[NH2:1][CH:2]1[C:8](=[O:9])[N:7]([CH3:10])[C:6]2[CH:11]=[CH:12][CH:13]=[CH:14][C:5]=2[N:4]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[C:3]1=[O:21].[C:22]([C:24]1[CH:25]=[C:26]([NH:30][C:31](N2C=CN=C2)=[O:32])[CH:27]=[CH:28][CH:29]=1)#[N:23]>C1COCC1>[C:22]([C:24]1[CH:25]=[C:26]([NH:30][C:31]([NH:1][CH:2]2[C:8](=[O:9])[N:7]([CH3:10])[C:6]3[CH:11]=[CH:12][CH:13]=[CH:14][C:5]=3[N:4]([C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=3)[C:3]2=[O:21])=[O:32])[CH:27]=[CH:28][CH:29]=1)#[N:23]

Participants

4

Reactant 2

HCID 14697649HCID 14697649, compoundHCID 19039453HCID 19039453, compound

Product 1

HCID 19039457HCID 19039457, compoundYield 93.7%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

3-Amino-1-methyl-5-phenyl-2,3,4,5-tetrahydro-2,4-dioxo-1H-1,5-benzodiazepine (360 mg) was suspended in dry THF (10 ml) under nitrogen. N-(3-cyanophenyl)-1H-imidazole-1-carboxamide (326 mg) was added, and the mixture stirred at room temperature for 2 h. The mixture was filtered to give the title compound (510 mg) as a white solid m.p.>250°.

Workup

  1. filtrationThe mixture was filtered

Sources & evidence

ORD record
ord-72b255aac3ce4621b159a51f352cbc80
Source dataset
uspto-grants-1997_06
Patent number
US05641775

Reaction notes

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