Diethylamine → 2-(N,N-diethylaminomethyl)-4-(3,4-dimethoxyphenyl)-3-hexanoyl-6,7-dimethoxyquinoline

HRID 1684593Notes

Reaction equation

HRID 1684593 reaction equation
Br[CH2:2][C:3]1[C:12]([C:13](=[O:19])[CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])=[C:11]([C:20]2[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[C:22]([O:28][CH3:29])[CH:21]=2)[C:10]2[C:5](=[CH:6][C:7]([O:32][CH3:33])=[C:8]([O:30][CH3:31])[CH:9]=2)[N:4]=1.[CH2:34]([NH:36][CH2:37][CH3:38])[CH3:35]>>[CH2:34]([N:36]([CH2:2][C:3]1[C:12]([C:13](=[O:19])[CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])=[C:11]([C:20]2[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[C:22]([O:28][CH3:29])[CH:21]=2)[C:10]2[C:5](=[CH:6][C:7]([O:32][CH3:33])=[C:8]([O:30][CH3:31])[CH:9]=2)[N:4]=1)[CH2:37][CH3:38])[CH3:35]

Participants

3

Reactant 2

HCID 8021DiethylamineHCID 190398982-Bromomethyl-4-(3,4-dimethoxyphenyl)-3-hexanoyl-6,7-dimethoxyquinoline

Product 1

HCID 544183392-(N,N-diethylaminomethyl)-4-(3,4-dimethoxyphenyl)-3-hexanoyl-6,7-dimethoxyquinoline

Procedure

According to the same manner as that described in Example 1, 2-bromomethyl-4-(3,4-dimethoxyphenyl)-6,7-dimethoxy-3-hexanoylquinoline was reacted with diethylamine to give 2-(N,N-diethylaminomethyl)-4-(3,4-dimethoxyphenyl)-3-hexanoyl-6,7-dimethoxyquinoline. This compound was recrystallized from ethyl acetate - hexane to give colorless prisms. mp. 104°-106° C.

Sources & evidence

ORD record
ord-1938e9e4417a48f69cf37b2d334517fe
Source dataset
uspto-grants-1997_06
Patent number
US05641788

Reaction notes

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