Isopropanol → HCID 23079493, compound

HRID 1684967Notes

Reaction equation

HRID 1684967 reaction equation
C([N:8]1[CH:16]=[N:15][C:14]2[C:9]1=[N:10][C:11]([CH2:18][CH2:19][C:20]([O:22][CH3:23])=[O:21])=[N:12][C:13]=2[NH2:17])C1C=CC=CC=1.C(O)(C)C.[H][H]>[OH-].[OH-].[Pd+2].C(O)=O>[CH3:23][O:22][C:20]([CH2:19][CH2:18][C:11]1[N:10]=[C:9]2[C:14]([NH:15][CH:16]=[N:8]2)=[C:13]([NH2:17])[N:12]=1)=[O:21]

Participants

6

Reactant 3

HCID 3776IsopropanolHCID 23079467HCID 23079467, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 23079493HCID 23079493, compoundYield 92.5%

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 284Formic AcidSolvent

Procedure

9-Benzyl-2-(2-methoxycarbonylethyl)adenine (0.29 g, 0.93 mmol) obtained by Example 61 and 20% Pd(OH)2/C (0.32 g) were added to a mixed solvent of isopropanol (8 ml) and formic acid (8 ml), and the mixture was stirred at a pressure of 2 atmosphere of hydrogen at 70° C. for 40 hours. After filtration, the filtrate was concentrated to give the captioned compound (0.23 g, 0.86 mmol) as a white solid.

Workup

  1. filtrationAfter filtration
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-f9cf083f6b1a49699065654ac601a27f
Source dataset
uspto-grants-2012_04
Patent number
US08148371B2

Reaction notes

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