Hydrochloric Acid → HCID 23079491, compound

HRID 1684968Notes

Reaction equation

HRID 1684968 reaction equation
[Na].Cl[C:3]1[N:11]=[C:10]2[C:6]([NH:7][CH:8]=[N:9]2)=[C:5]([NH2:12])[N:4]=1.O.Cl.[CH3:15][O:16][CH2:17][CH2:18][OH:19]>>[CH3:15][O:16][CH2:17][CH2:18][O:19][C:3]1[N:11]=[C:10]2[C:6]([NH:7][CH:8]=[N:9]2)=[C:5]([NH2:12])[N:4]=1

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 962WaterHCID 80192-MethoxyethanolHCID 949042-ChloroadenineHCID 5360545Sodium

Product 1

HCID 23079491HCID 23079491, compoundYield 73%

Procedure

After sodium (3.00 g, 130 mmol) was dissolved in 2-methoxyethanol (150 ml), thereto was added 2-chloroadenine (3.00 g, 17.69 mmol) and the mixture was refluxed for 8 hours. After the mixture was allowed to cool, water (400 ml) was added thereto and neutralized with concentrated hydrochloric acid. The resulting precipitate was filtered and washed with methanol to give the captioned compound (3.06 g, 14.48 mmol, yield 73%) as a white solid.

Workup

  1. temperaturethe mixture was refluxed for 8 hours
  2. temperatureto cool
  3. filtrationThe resulting precipitate was filtered
  4. washwashed with methanol

Sources & evidence

ORD record
ord-c4932f3ab0e6473482ce2e815daa27dc
Source dataset
uspto-grants-2012_04
Patent number
US08148371B2

Reaction notes

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