Ethylamine → HCID 86661276, compound

HRID 1685007Notes

Reaction equation

HRID 1685007 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][C:19]=1[Cl:20])[CH2:5][NH:6][C:7]([NH:9][C:10]1[S:11][CH:12]=[C:13]([CH2:15]I)[N:14]=1)=[O:8].[CH2:21]([NH2:23])[CH3:22]>O1CCCC1>[Cl:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][C:19]=1[Cl:20])[CH2:5][NH:6][C:7]([NH:9][C:10]1[S:11][CH:12]=[C:13]([CH2:15][NH:23][CH2:21][CH3:22])[N:14]=1)=[O:8]

Participants

4

Reactant 2

HCID 6341EthylamineHCID 58055059HCID 58055059, compound2×

Product 1

HCID 86661276HCID 86661276, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The 1-(3,4-dichloro-benzyl)-3-(4-iodomethyl-thiazol-2-yl)-urea (Intermediate 6, 0.3 mmol) was taken up in a 2.0 M solution of ethylamine in tetrahydrofuran (5 ml). Reaction was stirred at room temperature for 1 hour. The volatiles were removed in vacuo and the crude title compound was taken on as is, ˜75% pure.

Workup

  1. customReaction
  2. customThe volatiles were removed in vacuo

Sources & evidence

ORD record
ord-ffb93c545aa84d1abd32b0be5882851d
Source dataset
uspto-grants-2012_04
Patent number
US08148380B2

Reaction notes

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