Water → HCID 178429275, compound

HRID 1685219Notes

Reaction equation

HRID 1685219 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([OH:7])[NH:5][N:6]=1.O=[C:9]([CH3:15])[CH2:10][C:11](OC)=[O:12].O>Cl>[CH3:15][C:9]1[CH:10]=[C:11]([OH:12])[N:1]=[C:2]2[NH:6][N:5]=[C:4]([OH:7])[C:3]=12

Participants

5

Reactant 3

HCID 962WaterHCID 7757Methyl acetoacetateHCID 962215-Amino-1H-pyrazol-3-ol

Product 1

HCID 178429275HCID 178429275, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

20 g (201.8 mmol) of 5-amino-2H-pyrazol-3-ol and 26 g (224 mmol) of methyl 3-oxo-butyrate were heated under reflux in 63 ml of conc. hydrochloric acid and 17 ml of water for 1 h. After cooling, the product crystallized and was filtered off with suction and dried. Yield: 16.54 g (50%), M+H+: 166.07.

Workup

  1. temperatureAfter cooling
  2. customthe product crystallized
  3. filtrationwas filtered off with suction
  4. customdried

Sources & evidence

ORD record
ord-cddf479efdec40a09138557cb50cfbfc
Source dataset
uspto-grants-2012_04
Patent number
US08148395B2

Reaction notes

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