2-(2-isocyanatoethyl)thiophene → HCID 86628145, compound

HRID 1685223Notes

Reaction equation

HRID 1685223 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]2[NH:8][N:9]=[C:10]([OH:11])[C:5]2=[C:4]([CH3:12])[CH:3]=1.[N:13]([CH2:16][CH2:17][C:18]1[S:19][CH:20]=[CH:21][CH:22]=1)=[C:14]=[O:15]>C1COCC1>[S:19]1[CH:20]=[CH:21][CH:22]=[C:18]1[CH2:17][CH2:16][NH:13][C:14]([N:9]1[C:10](=[O:11])[C:5]2[C:6](=[N:7][C:2]([Cl:1])=[CH:3][C:4]=2[CH3:12])[NH:8]1)=[O:15]

Participants

4

Reactant 2

HCID 27821792-(2-isocyanatoethyl)thiopheneHCID 178426134HCID 178426134, compound

Product 1

HCID 86628145HCID 86628145, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In analogy to example 1c, 200 mg (1.09 mmol) of 6-chloro-4-methyl-1H-pyrazolo-[3,4-b]pyridin-3-ol were reacted with 183.5 mg (1.19 mmol) of 2-(2-isocyanatoethyl)-thiophene in THF at room temperature. Yield: 184 mg (50%), M+H+: 337.09.

Sources & evidence

ORD record
ord-192098d6eda9461c8b44eb443bf8a18e
Source dataset
uspto-grants-2012_04
Patent number
US08148395B2

Reaction notes

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