Methyl iodide → HCID 86628152, compound

HRID 1685232Notes

Reaction equation

HRID 1685232 reaction equation
[CH:1]1([NH:11][C:12]([N:14]2[C:22](=[O:23])[C:21]3[C:16](=[N:17][C:18]([Cl:25])=[CH:19][C:20]=3[CH3:24])[NH:15]2)=[O:13])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1.IC.N1[CH2:29]CCN2CCCCCC=12>CN(C=O)C>[CH:1]1([NH:11][C:12]([N:14]2[C:22](=[O:23])[C:21]3[C:16](=[N:17][C:18]([Cl:25])=[CH:19][C:20]=3[CH3:24])[N:15]2[CH3:29])=[O:13])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 86628150HCID 86628150, compound

Product 1

HCID 86628152HCID 86628152, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In analogy to example 2, 50 mg (0.14 mmol) of 6-chloro-4-methyl-3-oxo-1,3-dihydro-pyrazolo[3,4-b]pyridine-2-carboxylic acid (1,2,3,4-tetrahydronaphthalen-1-yl)amide were reacted with 23.85 mg (0.168 mmol) of iodomethane in DMF with 2,3,4,6,7,8,9,10-octahydropyrimido[1,2-a]azepine (DBU) at RT. Yield: 12 mg (23%), M+H+: 371.42.

Sources & evidence

ORD record
ord-1554757d69314408837d05f26af18c2f
Source dataset
uspto-grants-2012_04
Patent number
US08148395B2

Reaction notes

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