6-Azaindole → 3-(1,2,3,5,8,8a-Hexahydro-7-indolizinyl)-1H-6-azaindole

HRID 1685242Notes

Reaction equation

HRID 1685242 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[N:7][CH:8]=2)[CH:3]=[CH:2]1.[NH:10]1[CH2:14][CH2:13][CH2:12][CH2:11]1>C(O)C>[CH2:13]1[CH:14]2[N:10]([CH2:2][CH:3]=[C:4]([C:3]3[C:4]4[C:9](=[CH:8][N:7]=[CH:6][CH:5]=4)[NH:1][CH:2]=3)[CH2:5]2)[CH2:11][CH2:12]1

Participants

4

Reactant 2

HCID 92196-AzaindoleHCID 31268Pyrrolidine

Product 1

HCID 98812273-(1,2,3,5,8,8a-Hexahydro-7-indolizinyl)-1H-6-azaindole

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

from 6-azaindole (250 mg, 2.1 mmol), 1,2,3,5,6,8,8a-heptahydrohydro-7-oxo-indolizine (324 mg, 2.3 mmol) and pyrrolidine (1.2 g, 16.9 mmol) in ethanol (2 mL) heating at reflux for 6 hrs.

Workup

  1. temperatureat reflux for 6 hrs

Sources & evidence

ORD record
ord-e33c7ee25f53437ebf248e1d1d29d06d
Source dataset
uspto-grants-2012_04
Patent number
US08148394B2

Reaction notes

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