Iodoethane → 4778-76-1

HRID 1685598Notes

Reaction equation

HRID 1685598 reaction equation
C(OC(C1NC=CC=1)=O)C.C(I)C.[CH2:14]([N:16]1[CH:20]=[CH:19][CH:18]=[C:17]1[C:21]([OH:23])=[O:22])[CH3:15].[CH2:24]([O:26][C:27](=[O:35])[CH2:28][C:29]1[N:30]=[C:31]([NH2:34])[S:32][CH:33]=1)[CH3:25]>>[CH2:14]([N:16]1[CH:20]=[CH:19][CH:18]=[C:17]1[C:21]([OH:23])=[O:22])[CH3:15].[CH2:24]([O:26][C:27](=[O:35])[CH2:28][C:29]1[N:30]=[C:31]([NH:34][C:21]([C:17]2[N:16]([CH2:14][CH3:15])[CH:20]=[CH:19][CH:18]=2)=[O:23])[S:32][CH:33]=1)[CH3:25]

Participants

6

Reactant 4

HCID 6340IodoethaneHCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl esterHCID 255670Ethyl 1H-pyrrole-2-carboxylateHCID 154425984778-76-1

Product 2

HCID 154425984778-76-1HCID 43638978HCID 43638978, compound

Procedure

1-Ethylpyrrole-2-carboxylic acid (90 mg) was prepared from ethyl-pyrrole-2-carboxylate (140 mg, 1.0 mmol) and ethyl iodide (0.12 mL, 1.5 mmol) following the general procedures A and B. (2-{[1-Ethylpyrrole-2-carbonyl]-amino}-thiazol-4-yl)acetic acid ethyl ester (46 mg) was prepared from 1-ethylpyrrole-2-carboxylic acid (90 mg, 0.53 mmol) and 2-aminothiazol-4-yl acetic acid ethyl ester (95 mg, 0.53 mmol) following the general procedure F.

Sources & evidence

ORD record
ord-e8b8d30bc6cc4bb6b00aff444735e4e7
Source dataset
uspto-grants-2012_04
Patent number
US08148413B2

Reaction notes

Loading…