p-Cyanobenzyl alcohol → HCID 178513316, compound

HRID 1685722Notes

Reaction equation

HRID 1685722 reaction equation
CC1(C)OC(CO[C:9]2[C:18](C)=[CH:17][C:12]([C:13]([NH:15][OH:16])=[NH:14])=[CH:11][C:10]=2C)CO1.[OH:22][CH2:23]C1C=CC(C#N)=CC=1>C(N(CC)CC)C>[OH:16][NH:15][C:13](=[NH:14])[C:12]1[CH:11]=[CH:10][C:9]([CH2:23][OH:22])=[CH:18][CH:17]=1

Participants

4

Reactant 2

HCID 160549p-Cyanobenzyl alcoholHCID 178426655HCID 178426655, compound

Product 1

HCID 178513316HCID 178513316, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

The title compound is prepared in analogy to rac-4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-N-hydroxy-3,5-dimethyl-benzamidine (step b) starting from 4-hydroxymethyl-benzonitrile and using triethylamine as base; LC-MS: tR=0.21 min, [M+1]+=167.04.

Sources & evidence

ORD record
ord-c2a9cbc941bb4be896b4552ec594e448
Source dataset
uspto-grants-2012_04
Patent number
US08148410B2

Reaction notes

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