Trifluoroacetic acid → HCID 57699902, compound

HRID 1686002Notes

Reaction equation

HRID 1686002 reaction equation
[C:1]([NH:9][C:10]1[CH:42]=[CH:41][C:13]([O:14][C:15]2[C:24]3[C:19](=[CH:20][C:21]([O:27][CH2:28][CH2:29][C@H:30]([NH:34]C(C(C)(C)C)=O)[C:31]([OH:33])=[O:32])=[C:22]([O:25][CH3:26])[CH:23]=3)[N:18]=[CH:17][CH:16]=2)=[CH:12][CH:11]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:34][C@@H:30]([CH2:29][CH2:28][O:27][C:21]1[CH:20]=[C:19]2[C:24]([C:15]([O:14][C:13]3[CH:41]=[CH:42][C:10]([NH:9][C:1](=[O:8])[C:2]4[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=4)=[CH:11][CH:12]=3)=[CH:16][CH:17]=[N:18]2)=[CH:23][C:22]=1[O:25][CH3:26])[C:31]([OH:33])=[O:32]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67265368HCID 67265368, compound

Product 1

HCID 57699902HCID 57699902, compoundYield 111.9%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of (S)-4-[4-(4-benzoylamino-phenoxy)-6-methoxy-quinolin-7-yloxy]-2-tert-butylcarbonylamino-butyric acid (6.5 mg, 0.011 mmol) in DCM (1 ml) was added TFA (1 ml). The reaction was allowed to stir for 6 hours and then evaporated under reduced pressure to afford the title compound as an off-white solid (6.0 mg, 90% yield).

Workup

  1. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-e806d84fe4fe4df78fb821412ceade0e
Source dataset
uspto-grants-2012_04
Patent number
US08148531B2

Reaction notes

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